DoNotAge Pure Berberine (60 Capsules)
$49.80
Berberine supplement: Pure berberine alkaloid extract 500mg per capsule. DoNotAge.org formulation with research-grade purity, third-party tested and GMP certified. Vegan HPMC capsules with no fillers, designed for daily metabolic and cellular support.
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What is DoNotAge Pure Berberine and who is it for?
DoNotAge Pure Berberine is a concentrated extract of berberine alkaloid, a naturally occurring compound from Berberis species plants. It’s designed for adults interested in supporting metabolic wellness, glucose metabolism, and cellular energy pathways as part of a longevity-focused health strategy. This is an advanced supplement best used when foundational health is stable and you’re focusing on optimisation rather than addressing acute health concerns.
You might consider this if you’re interested in longevity science, researching AMPK activation pathways, or want to support metabolic resilience as part of a comprehensive wellness protocol. It works well alongside lifestyle factors like regular movement and dietary consistency, and many people incorporate it into multi-pathway longevity approaches.
Fairfield Nutrition Thoughts
Berberine represents one of the most rigorously studied plant alkaloids in metabolic and cellular research. The clinical literature demonstrates consistent activation of AMPK, a key metabolic regulator, which is genuinely compelling for anyone interested in longevity pathways. DoNotAge.org’s emphasis on research-grade purity and third-party testing aligns with how berberine is actually used in scientific studies, not just marketed as a supplement.
The evidence base here is substantial: multiple meta-analyses confirm berberine’s role in glucose metabolism and lipid profiles, and the AMPK activation mechanism has been well-characterised in both cell and animal models. Human trials are ongoing and emerging. What makes this particular product worth stocking is the commitment to purity standards that match what researchers actually use in trials, plus the transparent testing approach. This is berberine formulated for efficacy, not just convenience.
Why This Formulation / How It Works
Most berberine supplements prioritise cost over purity. DoNotAge.org inverts this: they verify each batch at 98% purity and conduct both in-house and third-party testing, matching the standards used in clinical research. The vegan HPMC capsule format avoids gelatin while maintaining bioavailability, and the absence of fillers means you’re getting exactly what’s on the label. This matters because berberine’s effects are dose-dependent and purity-dependent.
Berberine functions as an activator of AMPK (AMP-activated protein kinase), sometimes called the metabolic master switch. This enzyme regulates how your cells sense energy availability and respond to metabolic demands. When activated, AMPK shifts cellular processes toward energy-generating pathways and away from energy-consuming anabolic processes, mimicking some of the cellular effects of caloric restriction and exercise at the molecular level.
AMPK Activation and Metabolic Regulation
Berberine crosses cell membranes and directly activates AMPK in tissues throughout your body, particularly in liver, muscle, and adipose tissue. This activation triggers a cascade of downstream effects: improved glucose uptake in muscle cells, enhanced fatty acid oxidation, and more efficient mitochondrial function. Research shows this translates to measurable changes in glucose metabolism and lipid profiles.
Role in Glucose and Lipid Metabolism
Berberine influences multiple points in glucose regulation: it improves insulin receptor sensitivity, enhances glucose uptake into cells, and modulates hepatic glucose production. For lipid metabolism, it reduces cholesterol synthesis and increases cholesterol clearance. These aren’t separate mechanisms but interconnected effects of AMPK activation and downstream signalling changes.
Cellular Energy Pathway Support
By activating AMPK, berberine enhances mitochondrial biogenesis and function, meaning your cells’ energy-producing organelles become more efficient. This is why research subjects often report improved energy and stamina, though these effects typically emerge over weeks of consistent use rather than acutely.
When to Consider This
This optimisation-focused formulation makes sense if you’re:
Actively researching longevity compounds and interested in AMPK activation as part of a multi-pathway protocol
Over 40 and prioritising metabolic wellness alongside diet and movement
Working with a practitioner on metabolic optimisation and want research-grade berberine that meets clinical trial standards
Important: Best used once foundational health is stable and major health goals have been addressed. This is a longevity-focused compound, not an acute intervention.
⚠️ Not suitable for: Pregnancy, breastfeeding, children, people taking medications affecting blood sugar or blood pressure (consult your healthcare provider first), those with liver disease or significant medication interactions
How to Use
Take one 500mg capsule daily with a meal containing carbohydrates to support absorption and minimise digestive sensitivity. Berberine is best taken with food, particularly meals with carbohydrate content, as this context enhances its metabolic effects. You can take it once daily or split the dose across two meals if preferred.
Each capsule contains 500mg of pure berberine HCl in a vegan HPMC capsule with no fillers or excipients. DoNotAge.org recommends consistent daily use for optimal metabolic support, with effects typically becoming noticeable after 2-4 weeks of regular use. Store in a cool, dry place away from direct sunlight; refrigeration is optional but can help preserve potency.
Ingredients
Per Capsule:
Pure Berberine HCl (98% purity) – 500mg
Other Ingredients: Hypromellose (HPMC) capsule
Allergen Information: Free from common allergens. Vegan and non-GMO.
Common Questions
How is berberine different from other metabolic support supplements?
Berberine has one of the largest research bases of any botanical compound for metabolic health, with multiple meta-analyses and clinical trials demonstrating AMPK activation. Unlike many supplements with primarily theoretical support, berberine’s mechanism in humans has been well-characterised. DoNotAge.org’s research-grade purity means you’re getting the same quality used in actual clinical studies.
How long before I notice effects?
Most people report noticing changes in energy, appetite, or metabolic markers (like fasting glucose) after 2-4 weeks of consistent daily use. Effects are typically gradual rather than acute, reflecting the time needed for AMPK activation to produce measurable downstream changes in metabolism.
Can I take this with other supplements?
Berberine can be used alongside most supplements. However, it may interact with certain medications (particularly those affecting blood sugar, blood pressure, or liver function), so consult your healthcare provider if you’re on prescription medications before starting.
Is this suitable if I have blood sugar concerns?
Berberine has substantial research supporting its role in glucose metabolism. If you have diagnosed blood sugar conditions or are taking related medications, work with your healthcare provider before introducing berberine, as dosing of other interventions may need adjustment.
Why does this cost more than some other berberine supplements?
DoNotAge.org verifies purity at 98% and conducts third-party testing to match clinical trial standards. Many cheaper berberine products contain significantly less active berberine than claimed. You’re paying for verified purity and research-grade quality, not just berberine powder in a capsule.
What should I take with Pure Berberine?
Pure Berberine can be taken alongside other supplements, such as Pure NMN, Vitamin D3, K2 & Magnesium, and SIRT6 Activator for comprehensive health support.
Warnings & Storage
Do not use if: Pregnant, breastfeeding, under 18 years old, taking medications affecting blood sugar or blood pressure without healthcare provider approval, or have liver disease or significant medication interactions
Cautions: Berberine may interact with medications metabolised by the liver or affecting glucose regulation. Consult your healthcare professional before use if you have pre-existing conditions, take prescription medications, or are considering berberine alongside other supplements.
Storage: Store in a cool, dry place away from direct sunlight. Refrigeration is optional but can help preserve potency. Keep out of reach of children.
Always consult your healthcare professional before use if you have any pre-existing conditions or are taking medications.
| Weight | 0.064 kg |
|---|---|
| GTIN | 7.31E+11 |
Brand
DoNotAge
DoNotAge Australia
Longevity-focused supplements for targeted and advanced nutritional supportIntroduction
DoNotAge is a science-led supplement brand focused on healthy ageing and longevity research, with an emphasis on compounds studied for their roles in cellular health, metabolic function, and age-related biological processes. Rather than general multivitamins or lifestyle supplements, DoNotAge products tend to focus on specific longevity-relevant pathways, drawing on emerging research in areas such as NAD⁺ metabolism, autophagy, mitochondrial function, inflammation, and cellular resilience. At Fairfield, we stock a curated range of DoNotAge products in Australia, selected for formulation quality, relevance to longevity science, and suitability for thoughtful, staged use.What makes DoNotAge different
Research-led longevity focus
DoNotAge concentrates on compounds that are actively studied in the context of ageing biology and lifespan research. Many products are aligned with mechanisms such as:- cellular energy and NAD⁺ pathways
- senescence and autophagy
- metabolic efficiency
- inflammatory and oxidative balance
Targeted and advanced formulations
Most DoNotAge products are not intended as foundational nutrition. Instead, they are typically used to:- support a specific pathway
- complement existing foundations
- be trialled, assessed, and adjusted over time
How to think about using DoNotAge products
We generally view DoNotAge supplements as targeted or advanced tools, best layered on top of solid foundations such as adequate protein, metabolic and digestive stability, and sleep, movement and lifestyle fundamentals. For a broader framework on approaching supplements thoughtfully, see our How to think about supplements guide. Foundations to consider first include:- adequate protein and micronutrient intake
- metabolic and digestive stability
- sleep, movement, and lifestyle fundamentals
🟢 Foundational DoNotAge supplements
Suitable as broader baseline support While most of the DoNotAge range is targeted or advanced, a small number of products can function as foundational longevity supports, particularly when supporting basic nutritional and metabolic needs. Foundational options we stock include:- Vitamin D3, K2 and Magnesium – we love this combination of vital vitamins and Magnesium
- Pure Omega-3 – fatty acids to support general inflammatory balance and cellular health
- Pure Creatine Monohydrate – foundational support for metabolic, muscular, and cellular energy needs
- Pure Collagen Peptides – structural protein support relevant to connective tissue and skin integrity
🟡 Targeted DoNotAge supplements
Best suited to specific pathways or defined goals Many DoNotAge products are best understood as targeted supports—useful when you have a clearer reason for intervening, and when you want something that can be trialled and reassessed. Examples from the range we stock include products focused on:- Polyphenols and flavonoids (e.g. quercetin, apigenin)
- Metabolic and insulin-related pathways (e.g. berberine))
- Sleep and circadian support (e.g. SureSleep)
- Gut and microbiome support (e.g. probiotic formulations)
- Mitochondrial support (e.g. CoQ10 forms)
- introduced with a clear rationale
- used alongside foundations
- reassessed based on tolerance and response
🔴 Advanced DoNotAge supplements
For experienced users and advanced longevity protocols Some DoNotAge products fall into a more advanced category, often explored by people already familiar with longevity concepts and research. These are generally more upstream, meaning they’re best introduced carefully and evaluated over time rather than judged by immediate symptom changes. Advanced options we stock include compounds commonly discussed in research around:- NAD⁺ metabolism (e.g. NMN, NR)
- autophagy and cellular recycling (e.g. spermidine, fisetin)
- mitochondrial and metabolic signalling (e.g. Ca-AKG)
- sirtuin-related pathways and cellular stress responses
- not essential for everyone
- best introduced one at a time
- reviewed carefully for individual response
Why buy DoNotAge from Fairfield
- Australian-based, stocked locally — dispatched from Melbourne
- Fast shipping on in-stock items
- Curated range rather than the full catalogue, prioritising usefulness over novelty
- Clear, conservative guidance — focused on understanding, not hype
DoNotAge products available at Fairfield
Browse the DoNotAge products we currently stock below. If you’re new to the brand, many people begin with foundational or targeted support before exploring more advanced longevity-focused compounds. Popular DoNotAge products include NMN, spermidine, fisetin, Ca-AKG, berberine, and CoQ10:
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