What is Magnesium Breakthrough and who is it for?
Magnesium Breakthrough combines seven different forms of magnesium in a single formula. Most magnesium supplements contain only one or two forms, typically magnesium oxide or citrate. This product provides magnesium glycinate, citrate, malate, taurate, chelate, orotate, and Sucrosomial® magnesium, along with vitamin B6, manganese citrate, and a fulvic-humic mineral blend.
This approach makes sense if you’re looking for a comprehensive magnesium supplement rather than targeting a single form. Each magnesium compound has different absorption characteristics and tissue distribution patterns. Glycinate and bisglycinate forms are chelated to amino acids. Citrate binds to citric acid. Malate combines with malic acid. Taurate pairs with the amino acid taurine. The Sucrosomial® form uses a phospholipid delivery matrix.
Why This Formulation / How It Works
Most magnesium supplements use a single inorganic salt like oxide or a single organic form like glycinate. This formula combines seven different magnesium compounds, each with distinct chemical structures that influence where they’re absorbed and which tissues they reach.
The formula includes vitamin B6 as pyridoxine-5-phosphate (the active form), manganese citrate, and a fulvic-humic mineral blend with goMCT® (medium-chain triglycerides from coconut). The capsules use hypromellose (plant-based) rather than gelatin, with minimal excipients: microcrystalline cellulose for structure and ascorbyl palmitate (a fat-soluble form of vitamin C) as a preservative.
Different Magnesium Forms, Different Tissue Distribution
Magnesium bisglycinate and glycinate are chelated forms where magnesium binds to the amino acid glycine. This chelation protects the magnesium as it moves through the digestive tract. These forms are found in research on muscle tissue and nervous system applications.
Magnesium citrate, malate, and taurate are organic acid salts. Citrate pairs with citric acid (found in the Krebs cycle), malate with malic acid (also involved in cellular energy pathways), and taurate with the amino acid taurine (concentrated in cardiac and skeletal muscle). These forms appear in studies examining muscle function and cellular energy metabolism.
Specialized Delivery Forms
Sucrosomial® magnesium uses a phospholipid matrix to surround magnesium oxide particles. This creates a protective barrier that may influence how the compound moves through the digestive system. Magnesium orotate combines magnesium with orotic acid, a compound involved in pyrimidine synthesis (part of DNA and RNA production).
Cofactor Support
Vitamin B6 functions as a cofactor in over 100 enzyme reactions, including those involved in amino acid metabolism and neurotransmitter synthesis. The formula uses pyridoxine-5-phosphate, which is already phosphorylated (the active form your body uses). Manganese serves as a cofactor for enzymes involved in bone formation, amino acid metabolism, and antioxidant function.
How to Use
The manufacturer recommends 2 capsules daily, providing 500 mg of elemental magnesium. Each serving contains approximately 71 mg from each of the seven forms, though the exact distribution varies by compound weight.
The formula can be taken with or without food. Organic magnesium salts (glycinate, citrate, malate, taurate) don’t require stomach acid for absorption, while inorganic forms may absorb better on an empty stomach. Some people find magnesium has a mild laxative effect when taken without food, particularly at higher doses.
BIOptimizers suggests a loading protocol for the first 4-6 weeks: starting with 3 capsules daily (1 morning, 1 afternoon, 1 before bed), increasing to 4 capsules in week 2, then 5 capsules in weeks 3-6, before returning to a maintenance dose of 2-4 capsules daily. This approach aims to replenish depleted stores more quickly than standard dosing.
Ingredients
Per 2 capsules:
Vitamin B6 (as Pyridoxine-5-Phosphate): 2 mg
Elemental Magnesium: 500 mg from:
– Magnesium Chelate
– Magnesium Bisglycinate
– Sucrosomial® Magnesium (as Magnesium Oxide)
– Magnesium Malate
– Magnesium Orotate
– Magnesium Taurate
– Magnesium Citrate
Humic/Fulvic Monoatomic Blend 10mg
Manganese (as Manganese Citrate): 1 mg
Other ingredients: Hypromellose (capsule), Microcrystalline Cellulose, Ascorbyl Palmitate, goMCT® (coconut-derived medium-chain triglycerides)
Allergen information: Free from dairy, gluten, and common allergens. Vegan-friendly capsules.
Common Questions
How is this different from single-form magnesium supplements?
Most magnesium supplements contain one or two forms, typically oxide or glycinate. This formula provides seven different magnesium compounds, each with different molecular structures and tissue distribution patterns. The idea is that different forms may be utilized differently throughout the body, though research on multi-form combinations versus single forms is limited.
Why does this contain vitamin B6 and manganese?
Vitamin B6 is included based on research showing it may influence magnesium absorption and cellular uptake. Manganese serves as a cofactor for several enzymes and is involved in bone metabolism alongside magnesium. The amounts are relatively small (1.3 mg B6, 0.5 mg manganese per serving).
Can I take this if I’m already taking a different magnesium supplement?
That would give you a higher total magnesium dose. The tolerable upper intake level for supplemental magnesium is 350 mg daily for adults (not including dietary magnesium). This product provides 500 mg per serving. Taking additional magnesium could exceed recommended limits and may cause digestive upset. If you’re taking other supplements containing magnesium, calculate your total intake.
What’s the difference between the capsules and the drink powder versions?
The capsule form contains all seven magnesium types. The drink powder versions contain different formulations with added electrolytes and flavoring. Check the specific product labels, as the magnesium forms and amounts differ between formats.
















