What is Methyl B-Complex and who is it for?
Methyl B-Complex is a liposomal B-vitamin formula designed for anyone whose methylation capacity needs support—whether they’re under-methylators needing more active B vitamins, or over-methylators who need a balanced approach. The formula delivers all eight essential B vitamins in bioavailable forms alongside trimethylglycine and milk thistle, addressing the reality that B vitamin status directly affects energy production, neurological function, detoxification, and mood regulation. If you’re dealing with stress, aging, low stomach acid, genetic variations like MTHFR polymorphisms, or simply inconsistent dietary B vitamin intake, this product bridges that gap with a delivery system designed to overcome the absorption challenges that make oral B vitamins difficult to utilise effectively.
What sets this apart is the formulation philosophy: it’s not a high-dose methylation sledgehammer, but a balanced daily formula that works for most people without triggering over-methylation side effects like irritability or mood disturbance. The liposomal delivery system matters here because it allows the B vitamins to bypass typical gut absorption limitations and reach circulation quickly, making this genuinely different from standard B-complex tablets or capsules that rely on intestinal absorption.
Fairfield Nutrition Thoughts
B vitamin insufficiency is genuinely common—stress, aging, low stomach acid, genetic variations, and dietary gaps all contribute to poor B status. Standard supplementation often fails because the gut absorption of B vitamins is inconsistent and easily compromised. Quicksilver’s liposomal delivery addresses this directly by bypassing absorption limitations, which matters clinically when you need reliable daily repletion.
The formulation is thoughtfully balanced: it includes both methylated forms (B12 as methylcobalamin, B6 as pyridoxine) and non-methylated forms (folate as calcium folinate, not methylfolate) to support methylation without triggering over-methylation sensitivity in individuals who react poorly to high-dose methylfolate. The inclusion of trimethylglycine and milk thistle adds genuine support for methylation pathways and liver function. Research supports B vitamins’ roles in energy production, neurotransmitter synthesis, and detoxification, and the liposomal delivery system has demonstrated superior bioavailability compared to conventional oral forms.
Why This Formulation / How It Works
Standard B-complex formulas face a fundamental problem: B vitamins are water-soluble and don’t absorb reliably through the intestinal wall, especially when stomach acid is low or gut function is compromised. Quicksilver’s liposomal delivery encapsulates the B vitamins in phospholipid spheres that protect them through the digestive tract and allow them to enter circulation directly, bypassing the absorption bottleneck entirely. This isn’t theoretical—liposomal delivery has demonstrated superior bioavailability in research and clinical practice, making it genuinely advantageous for anyone with absorption challenges.
The formula balances methylated and non-methylated B vitamins deliberately. Methylcobalamin (B12) and pyridoxine (B6) provide active, immediately available forms for individuals who need them. Calcium folinate (B9) is used instead of methylfolate because it’s more stable in a liposome and won’t over-methylate individuals who are sensitive to high-dose methylfolate—a real concern that causes mood disturbance in some people. This balanced approach means most people can use this daily without side effects.
Supporting Methylation Pathways
Methylation is a fundamental biochemical process—it regulates gene expression, supports detoxification, and underpins neurotransmitter synthesis. B vitamins serve as cofactors in these pathways: B12 and folate work together in methionine synthesis, B6 supports neurotransmitter production, and B2 and B3 are essential for energy metabolism. Trimethylglycine (betaine) provides an additional methyl donor, reinforcing the body’s capacity to methylate effectively. The liposomal delivery ensures these nutrients reach cells where they’re needed.
Energy Production and Neurological Function
B vitamins are fundamental to converting food into usable energy through the citric acid cycle and electron transport chain. B1, B2, B3, and B5 are direct participants in these processes. B12 and folate support red blood cell production and myelin formation, both critical for neurological function and sustained energy. When B vitamin status is poor, energy production falters and cognitive function declines. This formula addresses that directly by ensuring reliable daily B vitamin availability.
Liver and Detoxification Support
Milk thistle seed extract supports Phase 1 and Phase 2 detoxification in the liver, while B vitamins—particularly B6, folate, and B12—serve as cofactors in detoxification pathways. Together, they support the body’s natural capacity to process and eliminate metabolic waste and environmental compounds. This is especially relevant for individuals under chronic stress, where detoxification capacity is often compromised.
When to Consider This
Methyl B-Complex provides targeted support for methylation pathways and energy production. It makes sense if you’re:
Scenario 1: Dealing with MTHFR genetic variations or sensitivity to methylfolate and need a balanced B formula that won’t over-methylate you.
Scenario 2: Managing chronic stress, fatigue, or brain fog where B vitamin insufficiency is contributing to the problem.
Scenario 3: Working to support liver function and natural detoxification while addressing known B vitamin deficiency or absorption challenges.
Supplement strategy: Many people introduce this after establishing foundational nutrition through diet and identifying that B vitamin status is genuinely compromised. It’s commonly used alongside other targeted support (like liver support or methylation-focused protocols) once basic nutritional foundations are in place. This is typically an ongoing daily formula rather than short-term support, used to maintain B vitamin repletion rather than to correct acute deficiency.
⚠️ Not suitable for: Pregnancy or breastfeeding (consult your healthcare professional), individuals taking medications that interact with B vitamins, or those with hypersensitivity to any ingredient.
How to Use
Take 2 pumps (1 mL) by mouth daily. Hold the liquid in your mouth for 30-90 seconds before swallowing—this allows sublingual absorption and enhances bioavailability. Take on an empty stomach, at least 10 minutes before meals, to optimise absorption. Each pump delivers the full spectrum of B vitamins in a single dose.
The liposomal formulation is designed for rapid absorption, so timing matters; empty stomach administration ensures the liposomal particles aren’t competing with food for absorption capacity.
Ingredients
Per Serving (1 mL / 2 Pumps):
Thiamin (Vitamin B1) (as Thiamine HCl) 12 mg
Riboflavin (as Riboflavin-5-Phosphate) 3.6 mg
Niacin (as Niacin, Niacinamide) 10 mg
Vitamin B6 (as Pyridoxine HCl) 6.7 mg
Folate (as Calcium Folinate) 850 mcg DFE
Vitamin B12 (as Methylcobalamin) 500 mcg
Biotin 500 mcg
Pantothenic Acid (as Calcium d-Pantothenate) 125 mg
Phosphatidylcholine (from highly purified phospholipids)
Milk Thistle Seed Extract
Trimethylglycine (as betaine)
Other Ingredients: Water, glycerin, ethanol, tocofersolan, EDTA (as preservative), natural flavourings, natural citrus oils, natural mixed tocopherols
Allergen Information: Free from gluten, soy protein, and common allergens. Tested allergen-free.
Common Questions
Why do I need to take B vitamins daily if I eat a reasonable diet?
B vitamins are water-soluble, meaning your body can’t store them—they’re excreted daily. Stress, aging, low stomach acid, genetic variations, and even caffeine and alcohol consumption all deplete B vitamin status. Even with good diet, many people don’t absorb or retain enough B vitamins to meet their actual needs, which is why daily repletion is necessary.
Why is this formula balanced instead of high-dose methylated?
Some people are sensitive to high-dose methylfolate and methylcobalamin, experiencing mood disturbance, irritability, or overstimulation—a phenomenon called over-methylation. This formula includes both methylated forms (for those who need them) and non-methylated forms (calcium folinate for B9, which is bioavailable but won’t trigger over-methylation). This balance makes it suitable for most people without side effects.
How is liposomal delivery actually different from a regular B-complex capsule?
Liposomal delivery encapsulates the B vitamins in phospholipid spheres that protect them through stomach acid and allow them to enter circulation directly, bypassing intestinal absorption. Standard capsules rely on your gut to absorb water-soluble B vitamins, which is inconsistent and easily compromised by low stomach acid or gut dysfunction. Liposomal delivery is genuinely more bioavailable, especially for people with absorption challenges.
Can I take this if I’m on other supplements or medications?
B vitamins are generally well-tolerated, but some medications do interact with B vitamin metabolism. Consult your healthcare professional before use if you’re taking medications or other supplements, particularly those affecting folate metabolism or neurological function.
Warnings & Storage
Do not use if: Pregnant, breastfeeding, or planning to become pregnant without consulting your healthcare professional. Hypersensitive to any ingredient.
Cautions: If you have a history of mood disturbance or sensitivity to methylated supplements, start with one pump daily and monitor your response before increasing to the full dose. If you're taking medications that interact with B vitamins or affect methylation, consult your healthcare professional before use.
Storage: Store in a cool, dry place away from direct sunlight. Keep bottle upright and sealed tightly. Do not refrigerate.
Always consult your healthcare professional before use if you have any pre-existing conditions or are taking medications.






















