Seeking Health Hydroxo-Adeno B12 – 60 Lozenges
$37.50
B12 supplement: Hydroxocobalamin and adenosylcobalamin in methyl-free forms. Seeking Health lozenge formulation designed for those sensitive to methylated nutrients. Slower enzyme pathway delivery provides B12 support without the side effects some experience with methylated forms.
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What is Seeking Health Hydroxo-Adeno B12 and who is it for?
Hydroxo-Adeno B12 is a lozenge supplement combining two non-methylated forms of vitamin B12: hydroxocobalamin and adenosylcobalamin. It’s designed specifically for people who experience sensitivity to methylated nutrients (like methylcobalamin) but still need B12 support. If you’ve had nervousness, headaches, or rapid heartbeat from methylated B vitamins, this formulation offers an alternative pathway.
This product makes sense if you have digestive issues affecting B12 absorption, want to support energy production at the cellular level, or are working with a practitioner on methylation support but need a gentler form. The lozenge delivery bypasses your digestive system, which is particularly relevant if you have absorption challenges.
Fairfield Nutrition Thoughts
B12 deficiency is common and often overlooked, particularly in people with digestive issues, restricted diets, or certain genetic variations. Most B12 supplements come in methylated forms, which work well for many people but can trigger unwanted reactions in those sensitive to methyl donors. Seeking Health’s approach here is clinically sound: providing bioavailable B12 in forms that bypass the methylation step initially, allowing the body to generate methyl groups at its own pace.
The combination of hydroxocobalamin and adenosylcobalamin is well-reasoned. Hydroxocobalamin converts readily to both adeno and methyl forms as needed, while adenosylcobalamin is the mitochondrial form directly involved in energy production. Research supports both forms for B12 status and energy metabolism. The lozenge delivery is practical for anyone with absorption challenges.
Why This Formulation / How It Works
Most B12 supplements use methylcobalamin, which is already in the “activated” methyl form. For people sensitive to methyl donors, this can feel like too much, too fast. Seeking Health’s two-form approach gives your body more control over the pace. Hydroxocobalamin and adenosylcobalamin require a few additional enzyme steps before methyl groups are liberated, which many people find gentler and more tolerable.
The lozenge format matters here too. Rather than swallowing a capsule that relies on stomach acid and digestive enzymes, the lozenge dissolves in your mouth, allowing sublingual absorption directly into the bloodstream. This is particularly useful if you have low stomach acid, digestive inflammation, or conditions affecting nutrient absorption.
Role in Energy Production
Adenosylcobalamin is concentrated in your mitochondria, where it functions as a cofactor in the methylmalonyl-CoA mutase enzyme. This enzyme is critical in the pathway that converts certain fatty acids and amino acids into acetyl-CoA, a central molecule in cellular energy production. When B12 is low, this pathway stalls, which is why B12 deficiency often presents as fatigue.
Role in Methylation and Detoxification
Both forms of B12 support methylation reactions through the methionine synthase (MTR) enzyme, which requires cobalamin as a cofactor. Methylation is involved in DNA synthesis, neurotransmitter production, and phase II detoxification pathways. Hydroxocobalamin has additional research showing it can bind to cyanide and other environmental toxins, supporting the body’s normal detoxification processes.
When to Consider This
This formulation makes sense if you’re:
Experiencing digestive issues that affect nutrient absorption, including low stomach acid, inflammatory bowel conditions, or post-bariatric surgery status.
Noticing fatigue or low energy that hasn’t improved with diet alone, or you suspect B12 deficiency based on bloodwork.
Sensitive to methylated nutrients but need B12 support—you’ve tried methylcobalamin or methylfolate and experienced headaches, nervousness, or rapid heartbeat.
Supplement strategy: Hydroxo-Adeno B12 typically works well as a standalone B12 source, though many people introduce it alongside foundational gut support supplements if they’re addressing absorption issues. The lozenge format makes it easy to adjust dosing based on how you feel—start with half a lozenge and increase to a full lozenge if needed.
⚠️ Not suitable for: Children under 4 years old, people with cyanide exposure concerns (discuss with healthcare provider first), those taking certain medications that affect B12 absorption (consult your healthcare professional).
How to Use
Start with half a lozenge by mouth during the first week. Let it dissolve slowly and swallow. If you need more support, increase to one full lozenge as needed. You can take this as needed rather than daily, though many people find consistent use more effective for maintaining B12 levels.
Important timing: Don’t take within 5 hours of bedtime, as B12 can interfere with sleep for some people. The lozenge format means you’re getting absorption without digestive processing, so you don’t need to take it with food. Store in a cool, dry place away from direct sunlight and out of reach of children.
Ingredients
Per lozenge:
Hydroxocobalamin (Vitamin B12) — 1,000 mcg
Adenosylcobalamin (Vitamin B12) — 1,000 mcg
Other ingredients: Sorbitol, natural cherry flavor, magnesium stearate, microcrystalline cellulose
Allergen information: Free from common allergens. Suitable for vegetarian, vegan, and bariatric diets.
Common Questions
How is this different from regular methylcobalamin?
Methylcobalamin is already in the methyl form, which some people find overwhelming. Hydroxo-Adeno B12 uses non-methylated forms that your body converts more gradually, making it gentler for people sensitive to methyl donors. If you’ve had headaches or nervousness from methylated B vitamins, this is worth trying.
Will this actually help my energy?
If your fatigue is related to B12 deficiency, yes. Adenosylcobalamin is the form your mitochondria use directly for energy production. That said, if your fatigue has other causes (sleep, iron deficiency, thyroid), B12 alone won’t fix it. But if you suspect low B12, this is a solid option to trial for 4-6 weeks and see how you feel.
Can I take this if I’m pregnant or breastfeeding?
Yes—Seeking Health specifically notes this is suitable for pregnancy and breastfeeding. B12 is important during both periods. If you’re working with a healthcare provider, mention you’re taking it so they can monitor your B12 levels.
Why do I need to wait 5 hours after bedtime to take this?
B12 can be stimulating for some people and may interfere with sleep if taken too close to bedtime. If you find you sleep fine with it, you can adjust your timing—just start with the manufacturer’s guidance and notice how your body responds.
Warnings & Storage
Do not use if: You're under 4 years old, you have a known cyanide exposure concern (hydroxocobalamin binds cyanide; discuss with your healthcare provider first).
Cautions: If you're taking medications that affect B12 absorption (metformin, PPIs, H2 blockers), let your healthcare provider know you're supplementing. Some medications may reduce the effectiveness of B12 supplementation. If you have pernicious anemia or other B12 absorption disorders, work with your healthcare provider to monitor B12 levels.
Storage: Keep closed in a cool, dry place away from direct sunlight and out of reach of children.
Always consult your healthcare professional before use if you have any pre-existing conditions or are taking medications.
| Weight | 0.035 kg |
|---|---|
| Suggested Use | Take 1 capsule, as needed, just prior to consuming high histamine foods or drinks. Or, take away from food if wanting to support healthy histamine levels in the digestive tract. Use as directed by your healthcare professional. Do not take this supplement and knowingly eat foods you are allergic to – it will not prevent allergic reactions. |
| Warnings | Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies. |
Brand
Seeking Health
Seeking Health Australia
Practitioner-grade supplements designed for clarity, tolerance, and individual needs Seeking Health is a practitioner-focused supplement brand developed to support individual nutritional needs with a strong emphasis on formulation clarity and tolerance. Founded by Dr Ben Lynch, Seeking Health is best known for its work in areas such as methylation, histamine balance, gut health, and immune support. The brand offers a broad range of supplements — from everyday nutritional foundations to more targeted products for people who don’t respond well to standard formulations. At Fairfield, we stock a wide selection of Seeking Health products used by practitioners and individuals who want more control and predictability in how supplements affect them.What makes Seeking Health different
Designed for people who don’t tolerate “standard” supplements well
Many supplements are formulated with the assumption that everyone responds the same way. In practice, this often isn’t true. Seeking Health products are commonly chosen by people who:- feel overstimulated by certain vitamins (especially B vitamins)
- react poorly to additives or excipients
- need more flexibility around dose and form
- want supplements that can be adjusted rather than “one-size-fits-all”
How to think about using Seeking Health products
The range naturally divides neatly into the categories we like to use:- foundational products that suit many people and can be used long-term
- targeted products designed for specific patterns, sensitivities, or short-term support
🟢 Foundational Seeking Health products
Suitable for many people, including longer-term use Foundational products are typically used to support:- baseline nutrient intake
- nervous system and muscle function
- digestion and fat absorption
- general immune and metabolic health
- Optimal Multivitamin – comprehensive daily nutrient support with careful balance
- Multivitamin One – simplified daily multivitamin for those wanting fewer ingredients
- Optimal Magnesium – well-tolerated magnesium support for muscles and nervous system
- Vitamin C Plus – foundational antioxidant and immune support
- Vitamin D3 – baseline vitamin D support when sun exposure is limited
- Vitamin D3 + K2 – combined fat-soluble vitamin support for bone and cardiovascular health
- Fish Oil – omega-3 fatty acids for general inflammatory balance
- Digestive Enzymes – broad-spectrum enzyme support to assist digestion
- Optimal Man – foundational nutrient support formulated for male health needs
🟡 Targeted Seeking Health products
Best used for specific sensitivities or clearer needs A large part of the Seeking Health range is designed for more specific situations, particularly where standard supplements haven’t worked well. Targeted products are commonly used to support areas such as:- histamine sensitivity or intolerance
- methylation-related nutrient needs
- immune regulation
- gut-related reactivity
- stress and neurotransmitter balance
- added on top of foundations
- used with clearer intent
- reassessed rather than taken indefinitely
A practical note on individual response
Seeking Health products are intentionally flexible — which means responses can vary. Some people notice benefits quickly. Others may need to:- adjust dose
- simplify what they’re taking
- allow more time between introducing products
Why buy Seeking Health from Fairfield
- Australian-based, stocked locally — dispatched from Melbourne
- Fast shipping on in-stock items (same-day dispatch when ordered before 2pm)
- Wide Seeking Health range available in Australia
- Clear, conservative guidance — we prioritise understanding over upselling
Seeking Health products available at Fairfield
Browse the Seeking Health products we stock below. If you’re new to the brand, many people begin with foundational support before exploring more targeted options as needed.
