Intoleran DAO Plus
$69.50
Digestive enzyme supplement: Diamine Oxidase (DAO) at 30,000 HDU per capsule, with Quercetin (38 mg) and Vitamin C (20 mg).
Intoleran DAO Plus tablets have a stomach acid-resistant coating which allows release in the small intestine, which is where it can best breakdown histamine.
Only 2 left in stock
Ships same business day from Melbourne (orders before 2pm)
What is Intoleran DAO Plus and who is it for?
Intoleran DAO Plus is a digestive enzyme capsule providing Diamine Oxidase (DAO) alongside Quercetin and Vitamin C. DAO is the primary enzyme involved in breaking down histamine from food in the small intestine. This product is formulated for people who want enzyme support when eating histamine-containing foods such as aged cheeses, salami, red wine, sauerkraut, and fermented products.
Intoleran has specialised in digestive enzyme formulations since 2008, and DAO Plus reflects their focus on minimal-ingredient, high-purity products. The capsule format is practical: it can be opened and the individual tablets swallowed separately, making it accessible for those who have difficulty swallowing capsules. Suitable from age 4.
Fairfield Nutrition Thoughts
DAO Plus fills a specific gap: enzyme support at the point of eating histamine-containing foods. For people working on histamine wellness who aren’t ready to eliminate fermented foods, aged cheeses, or wine entirely, having a DAO enzyme on hand before meals provides a practical tool. It’s also relevant for those who’ve identified that their histamine challenges are primarily food-derived rather than driven by endogenous histamine production.
The evidence for exogenous DAO supplementation is still developing, but the mechanism is well-understood: DAO is the enzyme responsible for degrading dietary histamine in the gut lumen, and providing it through supplementation before a histamine-rich meal gives the intestinal environment more enzymatic capacity at the right moment. Intoleran’s formulation is well-considered, using enteric-coated DAO tablets within the capsule to protect the enzyme through stomach acid, combined with Quercetin and Vitamin C as complementary antioxidants. The product is gluten-free, soy-free, and developed by in-house dietitians, which aligns with the quality standards we look for.
Why This Formulation / How It Works
Most DAO supplements on the market offer the enzyme alone. DAO Plus adds Quercetin (38 mg) and Vitamin C (20 mg) to the formulation. Quercetin is a flavonoid found in many plant foods and is included here for its antioxidant activity. Vitamin C is included both for antioxidant activity and its role in immune function. The combination reflects Intoleran’s approach of building supporting nutrients around the primary enzyme rather than offering it in isolation.
The delivery format is worth understanding. Each capsule contains four small tablets rather than a standard powder fill. The white/beige DAO tablets are coated with a stomach acid-resistant layer, which is essential: DAO is a protein-based enzyme and would be degraded by stomach acid before reaching the small intestine where it needs to function. The brown tablet carries Vitamin C and the green tablet carries Quercetin. For people who can’t swallow the whole capsule, it can be opened and the tablets swallowed separately without chewing.
DAO’s Role in Intestinal Histamine Metabolism
Diamine Oxidase is an enzyme produced in the intestinal mucosa that functions in the gut lumen to oxidatively deaminate histamine, rendering it inactive before it can be absorbed into the bloodstream. When dietary histamine load is high or endogenous DAO activity is low, more histamine passes through the gut wall into circulation. Providing DAO exogenously before a meal increases the enzymatic capacity available in the small intestine during digestion of that meal. The enzyme remains active for approximately 3 to 4 hours as the enteric-coated tablets dissolve gradually.
Antioxidant Activity of Quercetin and Vitamin C
Both Quercetin and Vitamin C provide antioxidant activity in their respective biochemical roles. Vitamin C is a water-soluble antioxidant involved in several enzymatic reactions and is a cofactor in immune function. Quercetin is a polyphenolic flavonoid that provides antioxidant activity in gut tissue and is found naturally in foods including onions, apples, and capers. Their inclusion in DAO Plus reflects a broader compositional approach to histamine wellness support rather than relying on the enzyme alone.
When to Consider This
This enzyme supplement provides support for histamine wellness around meals. It makes sense if you’re:
- Working with a practitioner or dietitian on a histamine wellness protocol and want enzyme support at mealtimes as part of that approach.
- Navigating social situations or travel where avoiding high-histamine foods isn’t always practical, and you want a tool to use before those meals.
- In a phase of reintroducing histamine-containing foods after a period of dietary restriction, and want enzymatic support during that process.
Supplement strategy: Intoleran recommends pairing DAO supplementation with a low-histamine diet, particularly in the first 2 to 4 weeks, to allow histamine levels to settle before gradually reintroducing higher-histamine foods. DAO Plus is commonly used three times daily with meals during this initial phase, then adjusted based on individual response. Many people introduce this alongside dietary changes and work with a dietitian to sequence the protocol appropriately.
⚠️ Not suitable for: Children under 4 years of age. People with known allergies to porcine (pork-derived) ingredients, as the DAO enzyme is derived from porcine kidney protein extract. Pregnant or breastfeeding individuals should consult a healthcare professional before use.
How to Use
Take 1 capsule immediately before each meal. The timing matters: the enzyme needs to be present in the small intestine as histamine-containing food arrives, so taking it just before eating gives the enteric coating time to dissolve and the enzyme time to become active. The DAO enzyme remains active for approximately 3 to 4 hours after intake.
Maximum dose is 3 capsules per day (one per meal). If you have difficulty swallowing the capsule, twist it open and swallow the four small tablets separately without chewing. The enteric coating on the DAO tablets is important for function, so chewing is not recommended.
Intoleran recommends combining DAO Plus with a low-histamine diet, ideally under dietitian supervision, for the first 2 to 4 weeks to allow histamine levels to settle. After this initial period, histamine-containing foods can be gradually reintroduced and DAO dosing adjusted based on personal response. Their complementary product Cozidase provides copper, zinc, B6, and Vitamin C to support the body’s own DAO enzyme activity, and some people use both products as part of a broader histamine wellness approach.
Ingredients
Per capsule (containing 4 tablets):
Diamine Oxidase (DAO): 20,000 to 30,000 HDU (from porcine kidney protein extract with 7% diamine oxidase)
Quercetin: 38 mg
Vitamin C (L-ascorbic acid): 20 mg
Other ingredients: Microcrystalline cellulose, hydroxypropyl cellulose, potato starch, ethyl cellulose (glazing agent), hydroxypropyl methyl cellulose, magnesium stearate, sodium alginate, rice starch, medium chain fatty acids, stearic acid, oleic acid, dicalcium phosphate, sulfite ammonia caramel (colouring). Capsule shell: hydroxypropylmethylcellulose (vegetarian).
Allergen information: Contains porcine (pig) derived ingredients. Free from gluten and soy.
Common Questions
Can I take this if I follow a vegetarian or vegan diet?
The capsule shell is vegetarian (hydroxypropylmethylcellulose), but the DAO enzyme itself is derived from porcine kidney protein extract, which makes this product not suitable for vegans or vegetarians who avoid pork-derived ingredients. This is the case with most commercially available DAO supplements, as porcine kidney is currently the primary source for food-grade DAO enzyme.
Does this mean I can eat anything I want?
DAO Plus provides enzymatic support before histamine-containing meals, but it works best as part of a broader approach. Intoleran recommends pairing it with a low-histamine diet, particularly in the first few weeks, rather than using it as a standalone solution that allows unrestricted eating. Think of it as a tool to use within a managed approach, not a replacement for dietary awareness.
Why can’t I chew the tablets?
The DAO enzyme tablets have a stomach acid-resistant coating that protects the enzyme from being degraded in the stomach. Chewing would break this coating and expose the enzyme to stomach acid before it reaches the small intestine, where it needs to function. Swallowing the tablets whole (or separately if the capsule is opened) keeps the coating intact.
Warnings & Storage
Do not use if: You are allergic to porcine (pig) derived ingredients. Not suitable for children under 4 years of age.
Cautions: If you are pregnant, breastfeeding, or taking medications, consult your healthcare professional before use. Factors including stress, certain medications, alcohol, hormonal fluctuations, and sleep patterns can also influence histamine levels and may affect how well DAO supplementation works in isolation.
Storage: Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Always consult your healthcare professional before use if you have any pre-existing conditions or are taking medications.
| Weight | 0.08 kg |
|---|---|
| Dimensions | 4 × 4 × 10 cm |
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