Seeking Health Histamine Nutrients (formerly Histamine Block Plus) – 60 Caps
$85.50
Histamine support supplement: DAO2™ enzyme, SAMe, PQQ, and B-vitamin cofactors in capsule form.
Seeking Health formulation combining patented diamine oxidase with nutrient cofactors for multiple histamine metabolism pathways.
Only 8 left in stock
Ships same business day from Melbourne (orders before 2pm)
What is Histamine Nutrients and who is it for?
Histamine Nutrients is a multi-nutrient capsule formulated by Seeking Health to provide cofactors involved in histamine metabolism pathways. It combines a patented DAO enzyme (DAO2™) with SAMe, PQQ, B vitamins, zinc, and copper, targeting several of the enzymatic routes through which histamine is processed in the body. You might consider this if you’re working with a practitioner on histamine wellness.
Unlike single-enzyme DAO supplements, this formulation addresses multiple histamine metabolism pathways simultaneously. It’s designed to be taken as needed rather than daily, which makes it a flexible tool for people whose histamine exposure varies day to day. Suitable from age 4 and appropriate during pregnancy and breastfeeding, it fits a broader range of people than many histamine-focused supplements.
Fairfield Nutrition Thoughts
Histamine wellness is one of the more underappreciated areas in functional nutrition, partly because the symptoms are so varied and partly because single-nutrient approaches often fall short. Most DAO enzyme products address only one breakdown pathway, but histamine is metabolised through several routes, and each depends on different cofactors. This product is designed for people who’ve identified that histamine is a genuine issue for them, particularly those who’ve tried standard DAO supplements with limited results.
Why This Formulation / How It Works
Most histamine supplements contain only diamine oxidase (DAO), the enzyme responsible for breaking down histamine in the gut. Histamine Nutrients takes a broader approach by providing cofactors for multiple histamine-processing enzymes, including HNMT (which clears histamine inside cells via methylation), MAOA and MAOB (which metabolise biogenic amines), NAT2 (which converts histamine to acetyl histamine for urinary excretion), and ALDH (which processes aldehyde byproducts of histamine breakdown). The result is a formulation that works across more of the histamine metabolism network rather than targeting a single bottleneck.
The DAO enzyme used here is DAO2™, a patented, porcine kidney-derived diamine oxidase with standardised activity. This matters because DAO enzyme quality and activity can vary significantly between products. The remaining ingredients are not fillers; each is selected for a specific enzymatic role, and the formulation is methyl-sensitive friendly, meaning it avoids high-dose methylating compounds that can be problematic for some people.
DAO Enzyme and Gut Histamine Breakdown
DAO (diamine oxidase) is the primary enzyme responsible for breaking down histamine in the digestive tract. It functions extracellularly, deaminating histamine before it can be absorbed into circulation. Copper is a required cofactor for DAO activity, and vitamin C plays a role in DAO production and mast cell stability. The DAO2™ used here is derived from porcine kidney, a tissue naturally high in DAO concentration.
Methylation Pathway and Intracellular Histamine Clearance
HNMT (histamine N-methyltransferase) clears histamine inside cells by transferring a methyl group from SAMe to histamine, converting it to N-methylhistamine for excretion. SAMe is the body’s primary methyl donor and is included here to support this intracellular clearance route. Vitamin B6 (as pyridoxal-5-phosphate, the active form) serves as a cofactor in multiple amine-processing reactions, including those involved in neurotransmitter and histamine metabolism.
Aldehyde and Ammonia Metabolism
Histamine breakdown produces byproducts including aldehydes and ammonia, which require their own processing. Zinc, B1, and B3 are cofactors for ALDH (aldehyde dehydrogenase), which processes aldehyde intermediates. Alpha-ketoglutarate is involved in ammonia metabolism, supporting the normal clearance of this byproduct. B5 (pantothenic acid) is a cofactor for NAT2, which acetylates histamine for urinary excretion. B2 supports MAOA and MAOB enzyme activity.
When to Consider This
This formulation provides nutritional support across histamine metabolism pathways. It makes sense if you’re:
- Working with a practitioner on histamine wellness and looking for a multi-pathway approach beyond single DAO enzyme products.
- Someone who has tried standard DAO enzyme supplements with limited results and wants to address additional metabolic pathways.
Supplement strategy: Many people introduce this alongside dietary changes to reduce high-histamine food load. It’s designed for as-needed use rather than daily supplementation, so it fits naturally into a broader histamine wellness protocol. Seeking Health recommends combining with HistaminX (for histamine storage support) and ProBiota HistaminX (for microbiome-level histamine management) for a more comprehensive approach, though Histamine Nutrients can be used independently.
⚠️ Not suitable for: Those with pork or porcine allergies (contains porcine-derived DAO2™). Consult your healthcare practitioner prior to use.
How to Use
Take 1 to 2 capsules with food as needed. This product is designed for as-needed use, not necessarily daily supplementation. You may find you need it several times on high-exposure days and not at all on others. It can be taken during the day to provide histamine metabolism support, or in the evening when sleep onset is a consideration.
Dr. Ben Lynch (Seeking Health’s founder) advises against taking this when histamine levels are already in a healthy range, as histamine serves normal physiological functions and excessively low levels are also undesirable. Take it when you know or suspect histamine exposure is elevated, such as after high-histamine meals, during high-pollen seasons, or around environmental triggers.
Seeking Health recommends combining with HistaminX and ProBiota HistaminX for broader histamine wellness support, though Histamine Nutrients can be used independently based on your individual needs.
Ingredients
Per 2 capsules (suggested serving):
Vitamin C (as ascorbic acid) – 500 mg
Vitamin B1 (as thiamine HCl) – included as ALDH cofactor
Vitamin B2 (as riboflavin) – included as MAOA/MAOB cofactor
Vitamin B3 (as niacinamide) – included as ALDH cofactor
Vitamin B5 (as calcium pantothenate) – included as NAT2 cofactor
Vitamin B6 (as pyridoxal-5-phosphate) – active form
Zinc (as Albion® zinc bisglycinate chelate) – included as ALDH cofactor
Copper – included as DAO cofactor
DAO2™ (diamine oxidase from porcine kidney extract) – patented enzyme
SAMe (S-adenosyl-L-methionine) – primary methyl donor
Alpha-ketoglutarate – ammonia metabolism support
LifePQQ® (pyrroloquinoline quinone) – antioxidant compound
Note: Exact milligram amounts for individual B vitamins, copper, SAMe, alpha-ketoglutarate, and PQQ not confirmed from available manufacturer data. Refer to product label for complete amounts.
Allergen information: Contains porcine (pork) kidney extract. Free from gluten, dairy, soy, and common allergens otherwise. Suitable for bariatric, methyl-sensitive individuals, pregnancy, and breastfeeding.
Common Questions
How is this different from a standard DAO enzyme supplement?
Standard DAO supplements provide only the diamine oxidase enzyme for gut histamine breakdown. Histamine Nutrients adds cofactors for four additional histamine-processing enzymes (HNMT, MAOA, MAOB, NAT2, ALDH), plus SAMe for the methylation-based intracellular clearance pathway. If you’ve tried a DAO-only product with limited results, the multi-pathway approach here is worth considering.
Do I need to take this every day?
No. This is designed for as-needed use. Take it when you know histamine exposure is likely to be elevated, such as before or after high-histamine meals, during high-pollen periods, or around environmental triggers. On days when you’re not experiencing elevated histamine exposure, you don’t need to take it.
Is this safe during pregnancy and breastfeeding?
Seeking Health lists this as suitable during pregnancy and breastfeeding. That said, always consult your healthcare practitioner before adding any supplement during pregnancy or while breastfeeding, particularly given the SAMe content.
Can children take this?
Seeking Health lists this as suitable from age 4 and up. Dosing for children should be discussed with a healthcare professional familiar with the child’s health history.
Why does this contain PQQ?
PQQ (as LifePQQ®) is included for its antioxidant activity and its involvement in cellular energy pathways. Histamine metabolism generates oxidative byproducts, and PQQ provides antioxidant activity within that context. The research on PQQ is primarily preclinical, but the rationale for its inclusion in a histamine metabolism formula is reasonable given what’s known about its biochemical roles.
Warnings & Storage
Do not use if: You have a pork or porcine allergy (contains porcine kidney-derived DAO2™). Do not use if the inner tamper seal is damaged.
Cautions: Consult your healthcare practitioner prior to use, particularly if you are pregnant, breastfeeding, taking medications, or have a pre-existing health condition. SAMe may interact with antidepressant medications; discuss with your prescribing practitioner if relevant.
Storage: Store in a cool, dry place, away from direct sunlight, and out of reach of children.
Always consult your healthcare professional before use if you have any pre-existing conditions or are taking medications.
| Weight | 0.087 kg |
|---|---|
| Suggested Use | Take 1 capsule, as needed, just prior to consuming high histamine foods or drinks. Or, take away from food if wanting to support healthy histamine levels in the digestive tract. Use as directed by your healthcare professional. Do not take this supplement and knowingly eat foods you are allergic to – it will not prevent allergic reactions. |
| Warnings | Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies. |
| GTIN | 8.10E+11 |
You may also like..
May also help with histamine:
Choose variants
×| Product | Price |
|---|
