Seeking Health Homocysteine Nutrients ( formerly Homocystex Plus) -60 Caps


Homocysteine Nutrients supports heart and brain health by aiding methylation and homocysteine metabolism, containing bioactive B vitamins and betaine (TMG).

Only 3 left in stock

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Seeking Health Homocysteine Nutrients is a comprehensive blend designed to support heart health and cognitive function. This supplement provides bioactive forms of essential B vitamins—folate (L-5-methylfolate), vitamin B12 (methylcobalamin & adenosylcobalamin), vitamin B6 (P-5-P), vitamin B2 (riboflavin; R-5-P)—along with betaine (TMG). These components work synergistically to support healthy methylation processes and the normal breakdown of homocysteine, a factor in heart health.

  • Folate (L-methylfolate or 5-MTHF) aids in breaking down homocysteine and supports the methylation cycle.
  • Vitamin B12 (methylcobalamin & adenosylcobalamin) and Vitamin B6 (P-5-P) act as cofactors in homocysteine regulation, converting it into beneficial amino acids.
  • R-5-P (riboflavin 5’-phosphate) and Betaine (TMG) play crucial roles in converting homocysteine into methionine, supporting overall cardiovascular health.
  • Suitable for individuals seeking support for homocysteine metabolism, blood flow, and brain health.

Who may benefit:

  • Individuals with high homocysteine levels or those concerned about cardiovascular health.
  • People with genetic mutations like MTHFR that affect methylation and homocysteine metabolism.
  • Those looking to support cognitive function and overall brain health.

** The Therapeutic Goods Administration has not evaluated these statements. This product is not intended to diagnose, treat, cure or prevent any disease. If you need further support, please work with a Functional Medicine practitioner at Fairfield Nutrition.

More Info

Did your blood test results come back with high levels of homocysteine? Do you want to support healthy blood pressure and heart health? If so, your methylation cycle may need support.

Homocysteine Nutrients provides the 5 nutrients your body requires for optimal methylation. This unique formula supports the body’s normal homocysteine breakdown for heart health support.

Homocysteine Nutrients by Seeking Health supplies bioactive forms of four essential B vitamins along with betaine (TMG). These nutrients synergistically support healthy methylation and homocysteine metabolism.

Methylation is a critical process in your body. It is responsible for genetic expression, breaking down homocysteine, and many more vital biochemical functions.

Over 50% of the population has an MTHFR genetic mutation. This can slow down methylation in your body. A slowed methylation cycle can lead to elevated homocysteine levels. That’s because proper methylation is required to break down and clear homocysteine.

Several studies link high homocysteine levels with an increased risk of heart and blood flow problems. Amongst other ways, homocysteine increases cardiovascular risk by damaging the lining of the arteries, which may promote excessive blood clotting.

Elevated homocysteine levels have also been associated with cognitive and brain issues. Proper neurotransmitter metabolism relies on maintaining optimal methylation function as well.

Homocysteine breakdown requires the enzymes in your methylation pathway to be working properly. These enzymes need specific nutrients as “coenzymes” to make them run effectively.

Homocysteine Nutrients supplies the nutrient coenzymes needed by your methylation enzymes. These bioactive forms (listed in brackets) are efficiently utilized and well-tolerated by the body.

  • Folate (L-5-methylfolate)
  • Vitamin B12 (methylcobalamin & adenosylcobalamin)
  • Vitamin B6 (P-5-P)
  • Vitamin B2 (riboflavin; R-5-P)
  • Betaine (TMG)

These nutrients supply the necessary methyl groups and coenzymes to support your entire methylation pathway. By supporting methylation, you are also aiding the body’s natural breakdown of homocysteine.

Homocysteine Nutrients is a targeted heart health supplement designed by methylation expert Dr. Ben Lynch, ND. The nutrients included are in amounts and forms that are efficiently utilized and well-tolerated by the body.

Got MTHFR? Want to support healthy homocysteine levels? Need better methylation support? Talk to your practitioner about including Homocysteine Nutrients in your daily healthcare routine.

In 1969, Dr. Kilmer McCully suggested that elevated homocysteine levels (hyperhomocysteinemia) were associated with heart issues. Since then, thousands of studies have confirmed his theory of homocysteine as a cardiovascular risk factor. As a result, many practitioners recognize the importance of keeping levels of homocysteine in a healthy range. Normal homocysteine levels require a functioning methylation cycle, which depends on the activity of multiple enzymes.

The body maintains healthy homocysteine levels by regulating the activity of a number of enzymes. These enzymes are located in your methylation cycle. They collectively work to convert homocysteine into either methionine or cysteine, which are beneficial amino acids.

The human body carries out methylation reactions in every single cell. The methylation cycle begins with the amino acid methionine. Via the MAT1A enzyme, methionine is converted into SAMe (S-adenosylmethionine). Once SAMe donates its methyl group to make creatine, phosphatidylcholine (PC), melatonin, or hundreds of other compounds, it becomes homocysteine. If the cycle slows down here, homocysteine levels can build up and become problematic.

It is essential to keep the methylation cycle moving to maintain healthy homocysteine levels. The most critical enzymes involved in homocysteine metabolism include:

    • CBS (Cystathionine Beta Synthase): Converts homocysteine into cystathionine, and then cysteine. About half of this cysteine is used to make glutathione, the body’s most important antioxidant compound. Both the CBS enzyme and the following CTH enzyme need adequate levels of vitamin B6 in the form of pyridoxal-5′-phosphate (P-5-P) to function.
    • BHMT (Betaine Homocysteine Methyl Transferase): This enzyme facilitates the donation of a methyl group from trimethylglycine (TMG) to homocysteine to recycle it into methionine.
    • MTHFR (MethyleneTetraHydroFolate Reductase): This is the final enzyme that carries out the manufacturing of 5-MTHF. A form of folate called 5-Methyltetrahydrofolate (5MTHF) first donates a methyl group to cobalamin (B12) to make methylcobalamin. Then, methylcobalamin donates the methyl group to homocysteine, converting it into harmless methionine.
    • Unfortunately, the manufacturing of 5-MTHF is not easy. In addition, over 50% of the general population has an MTHFR gene mutation slowing down their MTHFR enzyme. Thus, taking only L-5-methylfolate is often insufficient for those with MTHFR mutations. Riboflavin in the form of riboflavin 5’-phosphate (R-5-P) is needed as a coenzyme for the MTHFR enzyme to work. If you have a gene mutation in this enzyme, having adequate amounts of R-5-P becomes increasingly important.


  • MTR (Methionine Synthase): This is the last enzyme in the methylation cycle. It accepts the methyl group from 5-MTHF and adds it back to homocysteine to synthesize methionine. This provides the body with more methionine to start the methylation cycle all over again.

Each of these enzymes relies on specific nutrients as coenzymes. These coenzymes act like a key to ignite methylation enzymes to work and run at an optimal pace. It is well known that deficiency can slow the function of these enzymes. With slower enzyme function, homocysteine levels may rise.

Most research focuses on vitamin B12 and folate (5-MTHF) deficiencies in relation to elevated homocysteine levels. However, riboflavin (R-5-P), betaine (TMG), and vitamin B6 (P-5-P) play equally important roles in maintaining healthy homocysteine levels.

Did your doctor say you have high homocysteine? This is a sign of poor methionine recycling. If you want to support proper methylation recycling, you may want to look at HomocysteX Plus or Methylate. Each was designed to support healthy homocysteine levels.

If you’re looking to support healthy homocysteine levels and optimal methylation, look no further than HomocysteX Plus by Seeking Health.

Suggested Use

Take 1 capsule daily with or without food, or as directed by your healthcare professional. Do not take within 5 hours of bedtime as it may interfere with sleep.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications.
Weight 0.092 kg
Suggested Use

Take 1 capsule, as needed, just prior to consuming high histamine foods or drinks. Or, take away from food if wanting to support healthy histamine levels in the digestive tract. Use as directed by your healthcare professional. Do not take this supplement and knowingly eat foods you are allergic to – it will not prevent allergic reactions.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies.


Seeking Health

Why Seeking Health?

Seeking Health is a distinguished brand in the wellness industry, renowned for its commitment to optimising health through high-quality supplements and educational resources. Spearheaded by Dr. Ben Lynch, a leading expert in methylation and nutrigenomics, Seeking Health offers a diverse range of products, including prenatal vitamins, multivitamins, probiotics, and supplements tailored for gut health, immune support, and methylation support.

Why Purchase Seeking Health from us in Australia?

  • Melbourne-Based and In Stock: Located in Melbourne, our clinic keeps a well-stocked inventory, allowing for quick access and fast delivery across the region.Same day delivery on orders placed before 2PM
  • Functional Medicine Expertise: As a functional medicine clinic, we recommend supplements based on scientific evidence and clinical experience, ensuring they align with your health needs.
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Seeking Health Homocysteine Nutrients ( formerly Homocystex Plus) -60 Caps

Only 3 left in stock