Name: DoNotAge Pure Apigenin (60 Capsules) - Fairfield Nutrition Shop
Brand: DoNotAge
SKU: DNA-APIG-60CAPS
Price: 94.50 AUD
Availability: InStock

Question 1

Why this formulation and how does it work?

Accepted Answer

Most apigenin products on the market are unstable. Apigenin is a fat-soluble flavonoid that oxidises and loses potency relatively quickly when not properly stabilised. DoNotAge addresses this by binding the apigenin to beta-glycosides, which protects the compound and maintains potency over time. The formulation is also unusually clean &#8211; the capsule contains pure apigenin powder and nothing else, which matters if you&#8217;re stacking multiple supplements and want to know exactly what you&#8217;re taking.
The product is sourced from grapefruit: naringin is extracted and then converted to apigenin through a synthetic process. It&#8217;s manufactured to GMP and ISO9001 standards, third-party tested to above 99% purity, and suitable for vegans. Each 250mg capsule is taken with a fat source to support absorption of this fat-soluble compound.
Role in CD38 Inhibition and NAD+ Metabolism
CD38 is an enzyme that increases significantly with age and is one of the primary drivers of declining NAD+ levels. Apigenin is considered one of the most potent known natural inhibitors of CD38. Preclinical research suggests that inhibiting CD38 activity can meaningfully affect NAD+ availability in tissues, which is why apigenin is often used alongside NAD+ precursors like NMN rather than as a standalone approach.
Antioxidant Activity and Cellular Signalling
Apigenin provides antioxidant activity through free radical scavenging and is involved in modulating inflammatory signalling pathways in preclinical models. Research has also demonstrated interactions with GABA-A receptors, which provides a plausible mechanism for the calming and sleep-related properties associated with chamomile &#8211; a plant naturally high in apigenin &#8211; in traditional use.

Question 2

When should I consider this product?

Accepted Answer

This optimization-focused supplement makes sense if you&#8217;re:

Already using NMN or NR and want to address CD38 activity as part of a more complete NAD+ strategy.
In a life stage (typically 40+) where cellular longevity support is a priority and foundational health is already stable.
Focused on sleep quality as part of a broader wellness routine and looking for a well-sourced, single-ingredient option.

Important: Best used once foundational health is stable and major health goals have been addressed. Apigenin is typically introduced after foundational supplements like magnesium, vitamin D, and omega-3s are established.
⚠️ Not suitable for: Pregnancy or breastfeeding, children under 18. Use with caution if taking blood-thinning medications or thyroid medications, or if you have a hormone-sensitive condition. Note that apigenin is derived from grapefruit and may interact with medications affected by grapefruit &#8211; consult your healthcare professional if relevant. One user review noted a cold sore occurrence during use; individuals prone to herpes simplex outbreaks may wish to discuss this with their practitioner.

Question 3

How do I use this product?

Accepted Answer

DoNotAge recommends taking 1-2 capsules per day (250-500mg), with a source of fat to support absorption of this fat-soluble compound. Timing is flexible &#8211; many people take it in the evening given its traditional calming associations, though it can be taken any time of day. Each capsule contains 250mg of pure apigenin with no other active ingredients.
DoNotAge recommends using Pure Apigenin alongside Pure NMN, Vitamin D3/K2/Magnesium, and their SIRT6 Activator as part of a broader longevity protocol, though Pure Apigenin can be used independently.

Question 4

How is this different from just drinking chamomile tea?

Accepted Answer

Chamomile contains apigenin, but in relatively small and variable amounts. A single 250mg capsule delivers a concentrated, standardised dose that would be difficult to replicate through dietary sources alone. The beta-glycoside stabilisation also ensures potency is maintained, which isn&#8217;t something you can control with herbal tea.

Question 5

Do I need to take this with NMN, or can I use it on its own?

Accepted Answer

You can use it independently. The CD38 inhibition mechanism is relevant whether or not you&#8217;re supplementing with NMN &#8211; it affects the rate at which your body degrades its own NAD+. That said, many people use apigenin alongside an NMN or NR supplement to address both sides of NAD+ metabolism simultaneously.

Question 6

Why does the manufacturer recommend taking it with fat?

Accepted Answer

Apigenin is fat-soluble, meaning it absorbs more readily when consumed alongside dietary fat. This doesn&#8217;t need to be a large meal &#8211; a small amount of fat (a handful of nuts, a teaspoon of olive oil, or a full meal) is sufficient.

Question 7

Is the 250mg dose per capsule high compared to other products?

Accepted Answer

Yes &#8211; many apigenin products on the market are dosed at 50mg. DoNotAge&#8217;s 250mg per capsule reflects the doses used in research contexts and the protocols associated with researchers like David Sinclair. Starting with one capsule and assessing your response before increasing is a reasonable approach.

Weight	0.049 kg
GTIN	7.31094E+11

DoNotAge Pure Apigenin (60 Capsules)

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