Maintaining the right pace of gastrointestinal motility is crucial for effective nutrient and fluid absorption, toxin elimination, and ensuring overall abdominal comfort. The regulation of GI motility is orchestrated by over 100 million neurons residing in the GI tract walls.
Referred to as the enteric nervous system, or the ‘digestive nervous system,’ these neurons engage in a complex dialogue using a variety of neurotransmitters and neurohormones to coordinate smooth muscle contractions.
Within the GI tract, serotonin and acetylcholine emerge as the key neurotransmitters promoting motility.
- Ages 18 and up
- Healthy gut motility and function support
As a dietary supplement, take 3 capsules, 1-2 times daily, between meals.
MotilPro 5-HTP Prokinetic Supplement Australia
MotilPro supports serotonergic and cholinergic neurotransmission in the G.I. tract (1).
5 Hydroxytryptophan (5-HTP) is absorbed by enterochromaffin cells in the epithelium and is decarboxylated to serotonin using pyridoxal 5′ phosphate as a cofactor (2).
Serotonin stimulates enteric neurons through activation of 5-HT4 receptors, which contribute to healthy motility (3).
Ginger modulates serotonin signalling by additional 5-HT4 stimulation and by modulating serotonin type 3 (5-HT3) receptors in the enteric nervous system and brain stem, supporting gastric emptying, intestinal transit, healthy visceral sensation and upper G.I. comfort (4).
Acetyl-l-carnitine supports autonomic neuronal health and contributes acetyl groups for the synthesis of acetylcholine (5)*
Motilpro is often recommended as a part of SIBO treatment protocol due to its prokinetic functions.
- Sanger GJ, et al. Eur J Pharmacol. 1986 Aug 15;127(3):179-85.
- Ahlman H, et al. Acta Physiol Scand. 1981 Jul;112(3):263-9.
- Wang L, et al. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G419-28.
- Huang Q, et al. Yakugaku Zasshi. 1990 Dec;110(12):936-42.
- White HL, et al. Neurochem Res. 1990 Jun;15(6):597-601.