Seeking Health’s B Complex Plus – 100 caps
$45.80
B-vitamin supplement: Eight essential B vitamins in active forms, including methylcobalamin, adenosylcobalamin, and 5-MTHF (Quatrefolic®), plus choline.
Seeking Health formulation using methylated and coenzymated B vitamin forms, with no folic acid or cyanocobalamin.
Only 4 left in stock
Ships same business day from Melbourne (orders before 2pm)
What is B Complex Plus and who is it for?
B Complex Plus is a high-potency B vitamin supplement from Seeking Health, providing all eight essential B vitamins in their active, coenzymated forms alongside choline. It’s designed for people who want a reliable daily B complex that their body can use directly, without the conversion steps required by synthetic forms like folic acid or cyanocobalamin. It’s particularly well-suited to those with MTHFR or MTRR genetic variations, people following vegan or vegetarian diets, and anyone whose diet or life circumstances may leave them running low on these water-soluble nutrients.
Because B vitamins are water-soluble, the body doesn’t store them, which means daily intake matters. B Complex Plus delivers over 100% of the daily value for all eight essential B vitamins in a single capsule, making it a practical option for people who want comprehensive B vitamin coverage without managing multiple separate supplements.
Fairfield Nutrition Thoughts
B vitamins are foundational in the sense that almost every biochemical process in the body has some dependency on them, but this particular formulation sits in targeted territory. The use of active forms, specifically 5-MTHF instead of folic acid, methylcobalamin and adenosylcobalamin instead of cyanocobalamin, and pyridoxal-5-phosphate instead of pyridoxine, makes a meaningful difference for people who carry common genetic variations affecting B vitamin metabolism. It’s not just a marketing distinction.
The evidence for active B vitamin forms over synthetic precursors is well-established, particularly for folate and B12 in the context of MTHFR variations. Seeking Health was built around this clinical insight by Dr. Ben Lynch, and the formulation reflects that depth of thinking. The inclusion of both methylcobalamin and adenosylcobalamin covers different metabolic roles of B12, and the addition of choline acknowledges the broader methylation picture. We stock this because it’s a genuinely well-constructed formula that removes the guesswork around conversion efficiency.
Why This Formulation / How It Works
The difference between this and a standard B complex from a pharmacy shelf comes down to form. Most budget B complexes use folic acid, cyanocobalamin, and pyridoxine, all of which require conversion steps in the body before they can be used. For people with common genetic variations like MTHFR or MTRR, those conversion steps are less efficient, which means a standard B complex may not deliver what the label suggests. B Complex Plus uses forms the body can work with directly: 5-MTHF (as Quatrefolic®) for folate, methylcobalamin and adenosylcobalamin for B12, and pyridoxal-5-phosphate for B6.
Seeking Health also made a deliberate choice to exclude folic acid entirely. Research has raised questions about unmetabolised folic acid accumulating in the body when intake exceeds conversion capacity, which is a real consideration for people taking multiple supplements or eating fortified foods. Using 5-MTHF sidesteps this concern entirely.
Role in Methylation Pathways
Methylation is a biochemical process that occurs billions of times per second in every cell, involving the transfer of a methyl group from one molecule to another. B vitamins, particularly folate, B12, and B6, serve as essential cofactors in these reactions. 5-MTHF is the form of folate that crosses the blood-brain barrier and participates directly in the methylation cycle, donating methyl groups that are used in DNA synthesis, neurotransmitter production, and other cellular processes. Choline is included as an additional methyl donor, supporting methylation capacity through a parallel pathway.
Cofactor Roles Across Cellular Processes
Beyond methylation, B vitamins function as cofactors in a wide range of enzymatic reactions. Niacin (B3) is a building block for NAD+, a coenzyme involved in the Krebs cycle and cellular energy metabolism. Riboflavin (B2) is involved in recycling glutathione through the glutathione reductase enzyme. Pantothenic acid (B5) is a cofactor in CoA synthesis, which plays a role in fatty acid metabolism and adrenal function. Pyridoxal-5-phosphate is involved in over 140 enzymatic reactions, including those related to amino acid metabolism, neurotransmitter synthesis, and homocysteine processing.
When to Consider This
This formulation provides support across methylation and cellular energy pathways. It makes sense if you’re:
- Someone with confirmed or suspected MTHFR or MTRR genetic variations who wants a folate and B12 source that doesn’t rely on conversion steps
- Following a vegan or vegetarian diet, where B12 and other B vitamins are less available from food sources
- Working with a practitioner on homocysteine levels or methylation support as part of a broader nutritional strategy
- In a life stage or circumstance with increased demands on cellular energy metabolism, such as pregnancy (this formula is listed as suitable for pregnancy and breastfeeding), high physical activity, or periods of significant physiological stress
- Looking to consolidate multiple individual B vitamin supplements into a single, well-formulated daily capsule
Supplement strategy: Many people introduce B Complex Plus as part of an initial nutritional foundation, often alongside magnesium and vitamin D. For those specifically focused on methylation support, it’s commonly used alongside other methylation-relevant nutrients such as trimethylglycine or additional choline sources, depending on individual needs and practitioner guidance.
⚠️ Not suitable for: Those sensitive to niacin flushing should take with food. People sensitive to methylated B vitamins (some individuals with certain mental health conditions respond poorly to high-dose methylfolate) should consult a healthcare professional before use. Not for use within 5 hours of bedtime as it may interfere with sleep.
How to Use
The suggested dose is 1 capsule daily, taken with food. Taking it with food is worth following for two reasons: it reduces the likelihood of niacin flushing, and B vitamins are generally better absorbed alongside a meal. Avoid taking within 5 hours of bedtime, as the formula may interfere with sleep in some people.
Each capsule provides over 100% of the daily value for all eight essential B vitamins. For most people, one capsule daily is sufficient. If you’ve been advised by a practitioner to take a higher dose, the formula can be split across the day, again with food and not close to bedtime.
Ingredients
Per 1 capsule:
Thiamin (as thiamin HCl) 50 mg
Riboflavin (as riboflavin 5′-phosphate sodium) 25 mg
Niacin (as niacinamide and niacin) 100 mg
Vitamin B6 (as pyridoxal 5′-phosphate) 20 mg
Folate (as 5-methyltetrahydrofolate, Quatrefolic®) 680 mcg DFE (400 mcg)
Vitamin B12 (as methylcobalamin and adenosylcobalamin, MecobalActive®) 50 mcg
Biotin 300 mcg
Pantothenic acid (as calcium pantothenate) 100 mg
Choline (as phosphatidylcholine and choline bitartrate) 100 mg
Quatrefolic® is a registered trademark of Gnosis S.p.A. MecobalActive® is a trademark of HEALTHTECH BIO ACTIVES, S.L.U.
Other ingredients: Hypromellose (capsule), microcrystalline cellulose, ascorbyl palmitate
Allergen information: Gluten-free and free of GMO markers. Free from folic acid and cyanocobalamin.
Common Questions
Why does this contain niacin that causes flushing?
The formula includes niacin (vitamin B3) in a form that can cause a temporary flushing response in some people, particularly on an empty stomach. This is a normal physiological response related to niacin’s role in vasodilation and is harmless. Taking the capsule with food significantly reduces or eliminates flushing for most people.
Is this suitable if I have an MTHFR variation?
Yes, this is one of the reasons the formula was designed the way it was. It uses 5-MTHF (Quatrefolic®) as the folate source rather than folic acid, which means the folate is already in the active form used in methylation pathways and doesn’t require the MTHFR enzyme to convert it. No folic acid is used in any Seeking Health product.
Can I take this if I’m pregnant or breastfeeding?
Seeking Health lists this formula as suitable for pregnancy and breastfeeding, as well as for children aged 4 and up. As with any supplement during pregnancy, it’s worth discussing with your healthcare provider to confirm it fits your overall prenatal nutrition plan.
Why might some people feel worse on methylated B vitamins?
A small number of people, particularly those with certain mental health conditions or specific genetic profiles, report feeling overstimulated or anxious when taking high-dose methylfolate or methylcobalamin. If you’ve had this experience with other methylated B supplements, it’s worth starting with a lower dose or discussing with a practitioner before use. Seeking Health also offers methyl-free B vitamin formulations for those who need them.
Warnings & Storage
Do not use if: Inner tamper seal is damaged. Avoid taking within 5 hours of bedtime as it may interfere with sleep.
Cautions: Contains niacin, which may cause a temporary flushing response in some individuals, particularly on an empty stomach. People sensitive to methylated B vitamins, including those with certain mental health conditions, should consult a healthcare professional before use. Suitable for pregnancy, breastfeeding, vegetarian, vegan, and bariatric use. Suitable for ages 4 and up.
Storage: Store in a cool, dry place, out of reach of children.
Always consult your healthcare professional before use if you have any pre-existing conditions or are taking medications.
| Weight | 0.101 kg |
|---|---|
| Suggested Use | Take 1 capsule, as needed, just prior to consuming high histamine foods or drinks. Or, take away from food if wanting to support healthy histamine levels in the digestive tract. Use as directed by your healthcare professional. Do not take this supplement and knowingly eat foods you are allergic to – it will not prevent allergic reactions. |
| Warnings | Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Block is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Block does not manage or address antibody-related or IgE-related food allergies. |
