What is Tru Niagen 300mg + Immune Bundle and who is it for?
This bundle pairs two Tru Niagen formulations: the 300mg Niagen® capsule for foundational NAD+ precursor support, and the Tru Niagen Immune capsule, which combines 100mg of Niagen® with vitamin C, vitamin D3, two forms of zinc, and selenomethionine. Together, they deliver a combined 400mg of nicotinamide riboside alongside a set of immune-relevant micronutrients at research-aligned doses.
It’s worth considering if you’re already interested in NR supplementation and want to layer in daily micronutrient support for immune wellness without managing multiple separate products. The bundle is designed for adults who want both cellular energy pathway support and foundational immune nutrition in a single daily protocol.
Fairfield Nutrition Thoughts
NAD+ precursors are interesting the underlying science around NAD+ and its role in cellular energy metabolism, DNA repair signalling, and sirtuin activity is genuinely well-established. What’s less settled is the degree to which oral NR supplementation translates those cellular roles into meaningful outcomes for generally healthy adults. That said, Niagen® is the most-studied form of NR, with 40+ human clinical trials, and the evidence for NAD+ elevation at 300mg daily is solid and reproducible.
The Immune addition is sensibly formulated. Rather than stacking trendy botanicals, it pairs NR with micronutrients that have established roles in immune cell function: vitamin D3, vitamin C, zinc (in two bioavailable forms), and selenomethionine. The rationale for combining these with NR is grounded in research suggesting NAD+ availability can be affected during periods of physiological demand.
Why This Formulation / How It Works
Most NR products on the market use generic nicotinamide riboside. Tru Niagen uses Niagen®, a patented and extensively studied form of NR that is the ingredient used in the majority of published human clinical trials on this compound. That distinction matters when you’re evaluating whether the research applies to the product you’re actually taking. The 300mg dose is the amount used in the clinical study demonstrating over 50% NAD+ elevation, and the Immune capsule adds 100mg more, bringing the daily NR total to 400mg.
The Immune formulation avoids proprietary blends entirely. Each ingredient is listed with its exact dose, and the micronutrient selection reflects established nutritional roles rather than speculative additions. Zinc is provided in two forms (citrate and gluconate) to broaden absorption characteristics. Selenium is delivered as selenomethionine, the organic form with well-documented bioavailability. VitD3® is a plant-derived vitamin D3, making the full formula vegetarian-friendly.
NR as an NAD+ Precursor
Nicotinamide riboside is a form of vitamin B3 that enters cells and is converted into NAD+ (nicotinamide adenine dinucleotide) via the salvage pathway. NAD+ is a coenzyme involved in hundreds of enzymatic reactions, including those in the mitochondrial electron transport chain, DNA strand break repair via PARP enzymes, and sirtuin-mediated cellular signalling. Oral NR supplementation at 300mg daily has been shown in multiple human studies to measurably elevate whole-blood NAD+ concentrations.
Micronutrient Roles in Immune Cell Function
Vitamin D3 receptors are expressed on most immune cells, and vitamin D3 is involved in modulating innate and adaptive immune responses at the cellular level. Vitamin C is concentrated in immune cells at levels many times higher than in plasma, where it participates in antioxidant activity and supports neutrophil and lymphocyte function. Zinc is a cofactor for over 300 enzymes and plays a structural role in immune cell signalling. Selenium, particularly as selenomethionine, is incorporated into selenoproteins that provide antioxidant activity in immune tissue.
When to Consider This
This bundle provides nutritional support across cellular energy pathways and immune wellness. It makes sense if you’re:
- Over 40 and interested in maintaining NAD+ levels as part of a broader cellular wellness approach, given that NAD+ concentrations naturally decline with age.
- Working with a practitioner on a protocol that includes NR supplementation and you want to consolidate your daily immune micronutrients into a single product.
- Going through periods of increased physiological demand (travel, seasonal changes, high training loads) where immune wellness and cellular energy metabolism are both relevant priorities.
Supplement strategy: Many people introduce NR supplementation after establishing foundational supplements like magnesium, omega-3s, and vitamin D. This bundle is often a logical next step for those who are already stable on foundational nutrition and want to add a well-researched NAD+ precursor alongside immune micronutrients in a consolidated format.
⚠️ Not suitable for: Pregnancy or breastfeeding without medical supervision, children under 18, individuals with known hypersensitivity to any listed ingredient. Consult your healthcare professional before use if taking medications or managing any health condition.
How to Use
Take one Tru Niagen 300mg capsule and one Tru Niagen Immune capsule daily, together with food. That’s 300mg of NR from the first capsule and 100mg from the Immune capsule, giving a combined daily NR dose of 400mg alongside the immune micronutrients.
Both capsules use vegetarian hypromellose shells and are free from animal-derived excipients. Tru Niagen recommends consistent daily use rather than intermittent supplementation, as NAD+ elevation is maintained through ongoing intake.
Ingredients
Tru Niagen 300mg
Each capsule contains:
Nicotinamide riboside chloride (Niagen®) – 300mg
Other ingredients: Microcrystalline cellulose, hypromellose (vegetarian capsule), magnesium stearate (vegetable source)
Tru Niagen Immune
Each capsule contains:
Nicotinamide riboside chloride (Niagen®) – 100mg
Ascorbic acid (vitamin C) – 180mg
Colecalciferol (VitD3®, vitamin D3) – 8.8mcg (350IU)
Zinc citrate dihydrate – 34.2mg (equiv. zinc 11mg)
Zinc gluconate – 27.9mg (equiv. zinc 4mg)
Selenomethionine – 220mcg (equiv. selenium 90mcg)
Other ingredients: Microcrystalline cellulose, hypromellose (vegetarian capsule), magnesium stearate (vegetable source)
Allergen information: Free from common allergens. Both capsules are vegetarian-friendly.
Common Questions
Why does the Immune capsule only contain 100mg of NR when the standard capsule has 300mg?
The Immune capsule is designed to be taken alongside the 300mg capsule, not instead of it. The 100mg contributes to a combined daily dose of 400mg NR, while leaving room in the capsule for the immune micronutrients at their full research-aligned doses.
Can I take this bundle if I’m already taking a multivitamin?
It depends on what’s in your multivitamin. The Immune capsule contains vitamin C (180mg), vitamin D3 (350IU), zinc (15mg total), and selenium (90mcg). If your multivitamin already contains these nutrients, check the combined totals against safe upper intake levels, particularly for zinc and selenium. A conversation with your healthcare professional is worthwhile here.
How long before I’d expect to notice anything?
NAD+ elevation in the blood has been measured within hours of the first dose in clinical studies, with significant increases documented within two weeks of daily use. Whether you notice subjective changes varies considerably between individuals and depends on your starting NAD+ status and overall health context.
Is this the same NR used in the published research?
Yes. Niagen® is the patented form of nicotinamide riboside used in the majority of published human clinical trials on NR. Over 65% of registered NR trials have used Niagen® as the study ingredient, which means the clinical data is directly applicable to this product.
Warnings & Storage
Do not use if: Pregnant or breastfeeding without medical supervision. Not recommended for children under 18. Do not use if you have a known hypersensitivity to any ingredient in either formulation.
Cautions: Consult your healthcare professional before use if you are taking any medications, have a diagnosed health condition, or are planning surgery. Selenium intake from all sources should be monitored to avoid exceeding safe upper limits.
Storage: Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.
Always consult your healthcare professional before use if you have any pre-existing conditions or are taking medications.

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